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Altogether, our facts provide evidence for your potential of mixing CX-5461 and PARPi for strengthening the cure of HR-deficient HGSOC. We reveal that CX-5461 boosts the artificial lethal conversation of PARPi with HRD and clearly demonstrate that CX-5461 has a unique mechanism of action to PARPi. Importantly, we characterized BRCA-mutated and MYC